Antiretroviral-Drug Concentrations in Semen
نویسندگان
چکیده
منابع مشابه
Antiretroviral drug concentrations in semen of HIV-1 infected men.
Because semen is a major vehicle for the sexual transmission of HIV-1, control of viral replication within the sanctuary of the male genital tract should be a goal of antiretroviral therapy. Local immune responses, virus specific factors, and the degree of viral and cellular trafficking all appear to be important in controlling viral replication and evolution. However, the most important factor...
متن کاملAntiretroviral-drug concentrations in semen: implications for sexual transmission of human immunodeficiency virus type 1.
The majority of human immunodeficiency virus type 1 (HIV-1) infections result from seminal transmission (17, 104). The size of the viral innoculum in seminal fluid is likely the major determinant of transmissibility. Current HIV prevention strategies include comprehensive population interventions promoting condom use, early diagnosis and treatment of sexually transmitted diseases, and education...
متن کاملSemen quality and drug concentrations in seminal plasma of patients using a didanosine or didanosine plus tenofovir containing antiretroviral regimen.
Data on the concentrations of didanosine (ddI) and tenofovir (TFV) in seminal plasma are sparse. Subtherapeutic drug concentrations within the lumen of the male genital tract may have implications for selection and transmission of drug-resistant HIV strains. On the other hand, sufficient penetration of these drugs into the male genital tract has potential toxic effects on the spermatozoa and th...
متن کاملHIV-1-RNA Decay and Dolutegravir Concentrations in Semen of Patients Starting a First Antiretroviral Regimen.
BACKGROUND The objective of this study was to quantify human immunodeficiency virus (HIV) type 1 RNA decay and dolutegravir (DTG) concentrations in the semen of HIV-infected patients receiving DTG-based first-line therapy. METHODS This was a prospective, single-arm, open-label study including 15 HIV-1-infected, antiretroviral therapy-naive men starting once-daily treatment with DTG (50 mg) ...
متن کاملDrug concentrations after topical and oral antiretroviral pre-exposure prophylaxis: implications for HIV prevention in women.
Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban, South Africa (Prof S S Abdool Karim MBChB, L Werner MSc, Prof Q Abdool Karim PhD); Department of Epidemiology, Mailman School of Public Health, Columbia University, NY, USA (Prof S S Abdool Karim, Prof Q Abdool Karim); and Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of ...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2000
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.44.4.1117-1118.2000